VCAC: Molecular Processes: mRNA Processing: Advanced Look: Polyadenylation

Questions? Comments? Please contact Dr. Phillip McClean or Christina Johnson.

Flythrough Tour

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CELLULAR PROCESSES

Atp Synthase

Electron Transport Chain

Protein Trafficking

Protein Modification

Protein Recycling

Insulin Signaling

Constitutive Secretion

Regulated Secretion

Mitochondrial Protein Transport

Photosynthesis (Light)

Photosystem II

Mitosis

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MOLECULAR PROCESSES

Transcription

Regulated Transcription

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HOME > mRNA PROCESSING > ADVANCED LOOK > 1.) CAPPING > 2.) CLEAVAGE > 3.) POLYADENYLATION

mRNA Processing: Advanced Look --> 3.) Polyadenylation

The final step in processing pre-mRNA is the addition of a poly(A) tail to its 3' end. Clicking on each of the thumbnail images will bring up a larger, labeled version of the described scene.

To see the Flash movie for the following sequence of images, click here.

	After cleavage, PAP slowly begins to create the poly(A) tail.
	After the tail has reached a short length, additional proteins bind to the mRNA and increase the rate at which the tail grows.
	When the tail has reached its full length, PAP is signaled to stop adding A residues, and the tail is completed.
	The result of mRNA processing is a strand of mRNA, complete with cap and poly(A) tail, ready for splicing.