Questions? Comments? Please contact Dr. Phillip McClean or Christina Johnson.

OVERVIEW
Flythrough Tour
~~~~~~~~~~~~
MOLECULAR PROCESSES
Transcription
Regulated Transcription
mRNA Processing
mRNA Splicing
Translation
Lac Operon
~~~~~~~~~~~~
CELLULAR PROCESSES
Protein Trafficking
Protein Modification
Protein Recycling
Insulin Signaling
Constitutive Secretion
Regulated Secretion
Mitochondrial Protein Transport
Mitosis
Meiosis
~~~~~~~~~~~~
CELLULAR ENERGY CONVERSION
Atp Synthase (Gradients)
Electron Transport Chain
Photosynthesis (Light Reaction)
Photosystem II
Glycolysis (Overview)
Glycolysis (Reactions)
Citric Acid Cycle (Overview)
Citric Acid Cycle (Reactions)
Energy Consumption
~~~~~~~~~~~~


NATIONAL SCIENCE FOUNDATION


U.S. DEPARTMENT OF EDUCATION

~~~~~~~~~~~~~
NDSU Virtual Cell YouTube
MCBE Home
Virtual Cell
WWWIC Home
Funding & Credits
~~~~~~~~~~~~~
HOME > mRNA splicing > ADVANCED LOOK > 1.) primary transcript > 2.) spliceosome
mRNA Splicing: Advanced Look --> 2.) Spliceosome

Splicing is controlled by a large protein complex known as the spliceosome. Clicking on each of the thumbnail images will bring up a larger, labeled version of the described scene.

To see the Flash movie for the following sequence of images, click here.

The spliceosome is built in several stages. First, one of the proteins from the complex binds near the GU sequence.

The growing protein complex then brings the 5' GU end of the intron to the pyrimidine-rich region, folding the 5' end of the intron over itself.

Here we see the spliceosome fully assembled. Several more proteins have joined to make the mature complex.

Once fully assembled, the splicesome undergoes a conformational change.

NEXT --> 3.) SPLICING

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.