Protein Trafficking (Golgi):
Advanced Look -->
Proteins from the rough endoplasmic reticulum (ER) must be further modified upon reaching the cis cisternae region of the Golgi apparatus. Clicking on each of the
thumbnail images will bring up a larger, labeled version of the
see the Flash movie for the following sequence of images,
Proteins are translated and modified with in the rough endoplasmic reticulum. In order to complete their modifications, they are transported in membrane-bounded vesicles to the cis side of the Golgi apparatus.
Transport vesicles from the rough ER fuse together and become the cis cisterna of the Golgi.
Once they reach the Golgi apparatus, additional modifications are made to the transported proteins by resident Golgi enzymes. These modifications are key in ensuring the proteins reach their final destinations once they leave the Golgi apparatus.
The Golgi apparatus is divided into distinct regions. These include the cis cisterna, nearest the ER, the centrally located medial cisternae, the trans cisterna, and the trans Golgi Network (TGN).